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Immunological investigation

when is necessary:

  • In any case of unexplained infertility, especially when the woman is young. (age<38)
  • In all cases with recurrent miscarriages, after in vitro or normal conceptions.
  • in all cases with multiple missed abortions (blighted ovum) (age<38)
  • In any case of repeated IVF failures due to bad egg quality/poor ovarian reserve, especially when the woman is young (age<38)
  • If there are other known autoimmune problems present, like rheumatoid arthritis, lupus, positive anti-nuclear antibodies ANA, IBS, thyroid dysfunction, or other immune disorders
  • women with a successful natural conception and pregnancy, followed by multiple miscarriages while trying to have a second baby
  • In the event of complications in a previous pregnancy, such as preterm labour, spontaneous rupture of membranes, pre-eclampsia or IUGR / SFD.
  • In all cases with inability to develop a suitable endometrial lining (endometrial thickness <7mm), during a normal or artificial cycle. A well known reason for failure during IVF and despite the embryo quality.

What is included:

Detailed medical analysis of the immunological background of the couple and identification of potential immunological imbalances. This is the most important step for the resolution.

Specialised blood tests in Greece and at Rosalind Franklin University in Chicago to confirm the immunological imbalance and to assess the current condition.

  • Activated peripheral NK cells and NK cell inhibition panel – NK cell Assay
  • TH1 /TH2 cytokine ratio (T helper cells)
  • Other indirect indicators for the immune system’s status, as Thyroid function, ANA, Coagulation status, general inflammatory status, Vit D level, Ferritin level, CRP, blood group, etc.